Different recurrence patterns after phototherapeutic keratectomy in the corneal dystrophy resulting from homozygous and heterozygous R124H big-H3 mutation - 03/09/11

Doi : 10.1016/S0002-9394(01)00824-8

Tomoyuki Inoue, MD ^a, Hitoshi Watanabe, MD ^a,⁎ , Shuji Yamamoto, MD ^a, Yumiko Inoue, MD ^a, Masaki Okada, MD ^a, Yuichi Hori, MD ^a, Naoyuki Maeda, MD ^a, Yoshitsugu Inoue, MD ^a, Kozaburo Hayashi, MD ^b, Yoshikazu Shimomura, MD ^c, Yasuo Tano, MD ^a
^a Department of Ophthalmology (T.I., H.W., S.Y., Y.I., M.O., Y.H., N.M., Y.I., Y.T.), Osaka University Medical School, Osaka, Japan
^b Kobe Institute of Health (K.H.), Kobe, Japan
^c Department of Ophthalmology, Kinki University School of Medicine, Kinki, Japan (Y.S.)

^*Inquiries to Hitoshi Watanabe, MD, Department of Ophthalmology, Osaka University Medical School, E-7, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan; fax: +81-6-6879-3458

Abstract

PURPOSE: To report the recurrence pattern of corneal deposits after phototherapeutic keratectomy in patients with corneal dystrophies resulting from homozygous and heterozygous Arg124His (R124H) mutation of the BIG-H3 gene.

METHODS: Slit-lamp examination was performed on patients with corneal dystrophy resulting from a genetically confirmed BIG-H3 R124H mutation.

RESULTS: The recurrence of corneal deposits after phototherapeutic keratectomy in patient with heterozygous R124H mutation was mild; the granular opacities occurred as spot lesions in the central cornea. The patient with a homozygous mutation had a more severe pattern, and the recurrent lesions were diffuse and occurred in the periphery between the corneal epithelium and laser-ablated stroma. The recurrence-free interval in homozygous patients was shorter.

CONCLUSION: The mutation genotype of BIG-H3 gene determines the recurrence pattern after phototherapeutic keratectomy.

Le texte complet de cet article est disponible en PDF.

Plan

Case 1

Case 2

☆	Supported in part by Grant-in-Aid 09671800 for Scientific Research from the Japanese Ministry of Education, Science, Sports and Culture, by a Health Science Grant from the Japanese Ministry of Health and Welfare, and by a grant from the Osaka Eye Bank Foundation (Dr. Watanabe).

Export

Vol 132 - N° 2

P. 255-257 - août 2001 Retour au numéro

Article précédent

Intraocular lens power calculations using corneal topography after photorefractive keratectomy
John G Ladas, Brian S Boxer Wachler, John D Hunkeler, Daniel S Durrie

| Article suivant

Serratia marcescens corneal ulcer as a complication of orthokeratology
Ko-Hua Chen, Tung-Mei Kuang, Wen-Ming Hsu

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Different recurrence patterns after phototherapeutic keratectomy in the corneal dystrophy resulting from homozygous and heterozygous R124H big-H3 mutation - 03/09/11

Abstract

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL