Brain damage in preterm newborns: Biological response modification as a strategy to reduce disabilities - 05/09/11
Abstract |
Substances that promote the growth and maturation of oligodendrocytes and their precursors might protect against white matter injury. We suggest that neuroprotection can also be provided by such modulators of fetal and neonatal inflammatory responses as antiinflammatory cytokines, cytokine-binding proteins, and cytokine-receptor blockers. We briefly describe inflammatory responses in the fetus and newborn and show how they might contribute to brain damage. We conclude with the possibility that so-called biological response modifiers, which are drugs that modulate these inflammatory responses, might reduce the risk of brain damage and disabilities.(J Pediatr 2000;136:433-8)
Le texte complet de cet article est disponible en PDF.Abbreviations : BRMs, ICAM-1, IL, IL-1ra, MS, TNF
Plan
 | Supported by United Cerebral Palsy Research and Educational Foundation (EH-003-98). |
| Reprint requests: Olaf Dammann, MD, Neuroepidemiology Unit, CA 505, Children’s Hospital, 300 Longwood Ave, Boston, MA 02115. |
Vol 136 - N° 4
P. 433-438 - avril 2000 Retour au numéro
Article précédent
- Cerebral syncope: New insights into an emerging entity
- Blair P. Grubb
- The use of low molecular weight heparin in pediatric patients: A prospective cohort study
- David Dix, Maureen Andrew, Velma Marzinotto, Karen Charpentier, Suzanne Bridge, Paul Monagle, Gabrielle deVeber, Michael Leaker, Anthony K.C. Chan, M.Patricia Massicotte
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?