Respiratory Muscle Function and Drive in Chronic Obstructive Pulmonary Disease - 05/09/11
Résumé |
Respiratory muscles are essential to alveolar ventilation. There is accumulating evidence that inspiratory muscle function is abnormal in chronic obstructive pulmonary disease (COPD). Moreover, the inspiratory muscles face an increased elastic and resistive load in COPD. The imbalance between the function of the inspiratory muscles and the load they are facing plays an important role in the genesis of dyspnea1 and hypercapnia.8, 82, 90 It has also been suggested that inspiratory muscle force could be an important determinant of survival in hospitalized patients with severe COPD.46 This article reviews the mechanisms of inspiratory muscle function impairment in COPD and the secondary adaptations occurring in muscle structure and drive to which they are submitted.
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| Address reprint requests to Marc Decramer, MD, PhD, Respiratory Muscle Research Unit, Laboratory of Pneumology, Katholieke Universiteit Leuven, Herestraat, 49, B-3000 Leuven, Belgium, e-mail: marc.decramer@uz.kuleuven.ac.be This work was supported by a grant: KULeuven OT/98/27, Fonds voor Wetenschappelijk Onderzoek-Vlaanderen grant numbers G.0175.99 and G.0189.97. |
Vol 21 - N° 4
P. 679-692 - décembre 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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