Lung Volume Reduction Surgery for Emphysema - 05/09/11
Résumé |
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with a variable pathophysiologic basis114 manifest by varying degrees of chronic airflow obstruction and hyperinflation. The incidence in the United States is estimated to be at least 14 million and the prevalence is rising.57, 80, 137 At least two million individuals suffer from (predominantly) emphysema, which is characterized by anatomic air space enlargement.33 The economic burden of COPD is huge and increases with more severe disease.74 Furthermore, a marked impairment in quality of life is noted in these patients as the disease progresses.43 Over the past 50 years, many advances have been made in the management of COPD. The American Thoracic Society recently published a detailed, evidence-based analysis of medical management that provides a stepped-care algorithm of bronchodilators and suggests a possible role for anti-inflammatory agents.2 Furthermore, a recent comprehensive review of pulmonary rehabilitation confirmed objective and subjective improvements with varying rehabilitation formats in patients with COPD.1 Despite these advances, many patients continue to experience incapacitating breathlessness and exercise limitation. Over the past 90 years, numerous surgical approaches have been devised to ameliorate symptoms in these patients.
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| Address reprint requests to Fernando J. Martinez, MD, 1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109–0360, e-mail: fmartine@umich.edu |
Vol 21 - N° 4
P. 819-848 - décembre 2000 Retour au numéro
Article précédent
- Mechanical Ventilation in Chronic Obstructive Lung Disease
- Jigme M. Sethi, Mark D. Siegel
- Lung Transplantation for Chronic Obstructive Pulmonary Disease
- Larry L. Schulman
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