Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs - 05/09/11
Abstract |
Objective: The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model. Study Design: A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation. Results: In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal. Conclusion: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model. (Am J Obstet Gynecol 2000;183:1119-23.)
Le texte complet de cet article est disponible en PDF.Keywords : Myelomeningocele, hindbrain herniation, fetal surgery, sheep
Plan
| ☆ | Reprint requests: Bettina W. Paek, MD, The Fetal Treatment Center, University of California at San Francisco, San Francisco, CA 94143-0570. |
Vol 183 - N° 5
P. 1119-1123 - novembre 2000 Retour au numéro
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