MECHANISMS TO EXPLAIN PANCREATIC DYSFUNCTION IN CYSTIC FIBROSIS - 06/09/11
Résumé |
The article focuses on three potential mechanisms by which cystic fibrosis (CF) may lead to exocrine pancreatic dysfunction. Although not all-inclusive, the hypotheses presented provide a framework through which defects in the CF gene product, CFTR (cystic fibrosis transmembrane conductance regulator), may lead to pancreatic exocrine dysfunction. Three potential mechanisms include (1) obstruction of pancreatic ducts by inspissated plugs, (2) inhibition of endocytosis in acinar cells, and (3) imbalance in membrane lipids in CF-regulated cells. Any of these abnormalities alone or in combination would explain the development of pancreatic exocrine insufficiency.
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| Address reprint requests to Steven D. Freedman, MD, PhD, Beth Israel Deaconess Medical Center, Dana 501, 330 Brookline Avenue, Boston, MA 02215, e-mail: sfreedma@caregroup.harvard.edu Supported by National Institutes of Diabetes and Digestive and Kidney Diseases Grant R01 DK-52765 and a grant from The Cystic Fibrosis Foundation. |
Vol 84 - N° 3
P. 657-664 - mai 2000 Retour au numéro
Article précédent
- HOW CYSTIC FIBROSIS AFFECTS PANCREATIC DUCTAL BICARBONATE SECRETION
- Manoocher Soleimani, Charles D. Ulrich
- HEREDITARY PANCREATIC ADENOCARCINOMA : A Clinical Perspective
- Randall E. Brand, Henry T. Lynch
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