Central hyperventilation related to administration of topiramate - 06/09/11
Doi : 10.1016/S0887-8994(99)00143-5
Antoinette L Laskey, MD 
, Dale E Korn, MD , Bhagwhan I Moorjani, MD , †, Nitin C Patel, MD , †, Joseph D Tobias, MD , ‡, ⁎
Department of Child Health, University of Missouri; Columbia, Missouri, USA
, Dale E Korn, MD , Bhagwhan I Moorjani, MD , †, Nitin C Patel, MD , †, Joseph D Tobias, MD , ‡, ⁎ Department of Child Health, University of Missouri; Columbia, Missouri, USA † Department of Neurology, University of Missouri; Columbia, Missouri, USA
‡ Department of Anesthesiology; University of Missouri; Columbia, Missouri, USA
*Communications should be addressed to: Dr. Tobias, Pediatric Critical Care/Pediatric Anesthesiology; Departments of Anesthesiology and Child Health; University of Missouri; Department of Child Health; M658 Health Sciences Center; One Hospital Drive, Columbia, MO 65212
Abstract |
Topiramate is a recently released antiepileptic agent used in the treatment of patients with refractory seizure disorders. In addition to its antiepileptogenic activities, it results in inhibition of carbonic anhydrase isoenzymes II and IV, which are present in the central nervous system. A 15-year-old female who presented with hyperpnea and primary respiratory alkalosis is reported. Other possible etiologies of the central hyperventilation syndrome were excluded. The problem resolved within 24 hours after discontinuing topiramate.
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© 2000
Elsevier Science Inc. Tous droits réservés.
Vol 22 - N° 4
P. 305-308 - avril 2000 Retour au numéro
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