Melatonin improves sleep-wake patterns in psychomotor retarded children - 06/09/11
, †, ⁎, Eli Shahar, MD ‡, Nir Peled, MD, PhD , Sarit Ravid, MD †, ‡, Peretz Lavie, PhD , Amos Etzioni, MD † Sleep Laboratory; Technion—Israel Institute of Technology, Haifa, Israel Abstract |
Five children with severe psychomotor retardation (mean age 8.2 ± 3.6 years) and irregular sleep-wake patterns underwent 1 week of wrist actigraphic monitoring before and after treatment with 3 mg melatonin. Three underwent multiple measurements of urinary sulfatoxymelatonin levels. Urine sulfatoxymelatonin levels were abnormally low, without any significant day/night differences. Melatonin treatment increased nighttime sleep from 5.9 ± 0.8 to 7.3 ± 0.5 hours (paired t test, P < 0.01) and sleep efficiency from 69.3% ± 6.2% to 88.3% ± 2.3% (P < 0.01). Daytime sleep decreased from 3.2 ± 1.2 to 1.7 ± 1.2 hours (P < 0.05). Thus, no change in 24-hour total sleep time (9.1 ± 1.5 vs 9.0 ± 1.6 hours) occurred. Administration of 3 mg melatonin to five severely psychomotor retarded children resulted in a significant improvement in their sleep-wake patterns.
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Vol 23 - N° 3
P. 225-228 - septembre 2000 Retour au numéro
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- Shin-Ichiro Hamano, Manabu Tanaka, Sakiko Kawasaki, Takahiro Nara, Hideki Horita, Yoshikatsu Eto, Saburo Kohno
- Melatonin for the treatment of handicapped children with severe sleep disorders
- Mohammed M.S Jan
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