Predictive value of acetylcholine stimulation testing for oligohidrosis caused by zonisamide - 06/09/11
Doi : 10.1016/S0887-8994(00)00144-2
Akihisa Okumura, MD 
, †, ⁎, Naoko Ishihara, MD , †, Toru Kato, MD †, Fumio Hayakawa, MD ‡, Kuniyoshi Kuno, MD †, Kazuyoshi Watanabe, MD
Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Aichi,Japan
, †, ⁎, Naoko Ishihara, MD , †, Toru Kato, MD †, Fumio Hayakawa, MD ‡, Kuniyoshi Kuno, MD †, Kazuyoshi Watanabe, MD Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Aichi,Japan † Department of Pediatrics, Anjo Kosei Hospital, Anjo, Aichi, Japan
‡ Department of Pediatrics, Okazaki City Hospital, Okazaki, Aichi, Japan
*Communications should be addressed to: Dr. Okumura, Department of Pediatrics, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan
Abstract |
We studied 16 patients for whom zonisamide was newly prescribed. Acetylcholine stimulation testing was performed about 1 month after zonisamide was initiated. Oligohidrosis occurred in none of the four with a normal response and in four of the 12 with a decreased response. Acetylcholine stimulation testing predicted oligohidrosis with a sensitivity of 1 and a false-positive rate of 0.67. The acetylcholine stimulation test was sensitive in detecting oligohidrosis caused by zonisamide, although the false-positive rate was high.
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© 2000
Elsevier Science Inc. Tous droits réservés.
Vol 23 - N° 1
P. 59-61 - juillet 2000 Retour au numéro
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