ANTIBODY DEFICIENCY SYNDROMES - 06/09/11

Doi : 10.1016/S0031-3955(05)70269-8

Ricardo U. Sorensen, MD ^{^{*
Division of Allergy/Immunology, Department of Pediatrics and the Allergy/Immunology Training Program, Louisiana State University Health Sciences Center, New Orleans, Louisiana}}, Cleveland Moore, MD ^{^{*
Division of Allergy/Immunology, Department of Pediatrics and the Allergy/Immunology Training Program, Louisiana State University Health Sciences Center, New Orleans, Louisiana}}

Résumé

Antibody deficiencies are, by far, the most commonly reported immunodeficiencies worldwide.^{20 Fasth A. Primary immunodeficiency disorders in Sweden: Cases among children, 1974–1979 J Clin Immunol 1982 ; 2 : 86-92 [cross-ref]

Cliquez ici pour aller à la section Références, 24 Hayakawa H., Iwata T., Yata J. , et al. Primary immunodeficiency syndrome in Japan: I. Overview of a nationwide survey on primary immunodeficiency syndrome J Clin Immunol 1981 ; 1 : 31-39 [cross-ref]

Cliquez ici pour aller à la section Références, 40 Luzi G., Businco L., Aiuti F. Primary immunodeficiency syndromes in Italy: A report of the national register in children and adults J Clin Immunol 1983 ; 3 : 316-320 [cross-ref]

Cliquez ici pour aller à la section Références, 41 Matamoros Flori N., Mila Llambi J., Español Boren T. , et al. Primary immunodeficiency syndrome in Spain: First report of the national registry in children and adults J Clin Immunol 1997 ; 17 : 333-339

Cliquez ici pour aller à la section Références, 69 Zelazko M., Carneiro-Sampaio M., Cornejo de Luigi M. , et al. Primary immunodeficiency diseases in Latin America: First report from eight countries participating in the LAGID J Clin Immunol 1998 ; 18 : 161-166 [cross-ref]

Cliquez ici pour aller à la section Références} The spectrum of antibody deficiencies ranges from severe deficiencies of all immunoglobulins (i.e., agammaglobulinemia) to milder, but clinically relevant, deficiencies of specific antibodies in patients with normal immunoglobulin concentrations. The prevalence of antibody deficiency syndromes typically increases with decreasing severity. IgA deficiency, which occurs in some asymptomatic individuals, is the commonest immunodeficiency.^{22 Hanson L.A., Bjorkander J., Oxelius V. Selective IgA deficiency Primary and secondary immunodeficiency disorders New York: Churchill Livingstone (1983).
62-84

Cliquez ici pour aller à la section Références} The various types of antibody deficiency are best understood after a brief review of the development and function of antibody-mediated immunity.

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Plan

DEVELOPMENT OF ANTIBODY-MEDIATED IMMUNITY

Antibody-Mediated Immunity

Classification of Antibody Deficiencies

Clinical Manifestations of Antibody Deficiency

GENERAL EVALUATION OF ANTIBODY-MEDIATED IMMUNITY

Agammaglobulinemia

Hyper-IgM Syndrome

Common Variable Immunodeficiency

Transient Hypogammaglobulinemia of Infancy

IgM Deficiency

IgA Deficiency

IgG Subclass Deficiencies

IgG1 Subclass Deficiency

IgG2 Subclass Deficiency

IgG3 Subclass Deficiency

IgG4 Subclass Deficiency

Specific Antibody Deficiency with Normal Immunoglobulins

RELATIONSHIP BETWEEN DIFFERENT FORMS OF ANTIBODY DEFICIENCY

SUMMARY

Address reprint requests to Ricardo U. Sorensen, MD Division of Allergy/Immunology Department of Pediatrics Louisiana State University Health Science Center 1542 Tulane Avenue New Orleans, LA 70112–2822