The management of acute pediatric pain can be accomplished using a multimodal approach in which pharmacologic techniques and cognitive–behavioral approaches complement one another. Traditionally, health care practitioners have approached pain management in children and adults as an “either/or,” that is, pharmacologic interventions or “alternative” approaches, and specialties defined which approach and intervention were used. Physicians rely primarily on drugs and invasive techniques to modulate nociceptive processing, whereas nurses, psychologists, and other nonphysicians primarily rely on nonpharmacologic approaches. “Either/or” does not provide optimal care or therapeutic options, however. Rather, cognitive–behavioral interventions, relaxation techniques, breathing exercises, transcutaneous electric nerve stimulation (TENS), biofeedback, and even acupuncture can supplement pharmacologic methods of pain management in children. This article discusses these complementary therapies and how using them may reduce or eliminate the amount of medication needed to treat the pain.