OPTIC GLIOMAS - 07/09/11
Résumé |
Primary tumors of the optic nerve are uncommon. Optic nerve gliomas (ONG) represent approximately 4% of all orbital tumors, 4% of all intracranial gliomas, and 2% of all intracranial tumors.2 They account for 66% of all primary optic nerve tumors. The main differential diagnosis for an ONG is an optic sheath meningioma.25 Gliomas are 4:1 more common than meningiomas. The peak age of occurrence ranges from 2 to 8 years old, with a girl to boy predominance of 3:2. Seventy-five percent of gliomas are diagnosed in the first decade and 90% are diagnosed in the first two decades.3 They can be solitary or a component of neurofibromatosis-1 (NF-1). If bilateral, they are considered to be pathognomic of NF-1. Ten percent to 38% of patients with ONG have NF-1 and 15% to 40% of patients with NF-1 have optic pathway gliomas.1 Fifty percent to 85% of all optic pathway gliomas involve the chiasm or the hypothalamus.27 Eighty percent of patients with NF-1 have optic nerve gliomas confined to the optic nerve alone.
This article discusses the anatomy of the optic pathway and the imaging and clinical manifestations of ONG. Other neoplasias, which mimic ONG, are discussed elsewhere in this issue.
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| Address reprint requests to Michael D. Hollander, MD, Department of Radiology, Division of Neuroradiology/Ear, Nose and Throat, Thomas Jefferson University Hospital, Suite 1072 Main Building, 132 South Tenth Street, Philadelphia, PA 19107 |
Vol 37 - N° 1
P. 59-71 - janvier 1999 Retour au numéro
Article précédent
- OPTIC NERVE SHEATH MENINGIOMAS : Role of MR Imaging
- Mahmood F. Mafee, James Goodwin, Shervin Dorodi
- SARCOIDOSIS OF THE EYE, ORBIT, AND CENTRAL NERVOUS SYSTEM : Role of MR Imaging
- Mahmood F. Mafee, Shervin Dorodi, Eugene Pai
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