Objectives. To test the hypothesis that an interactive multimedia-based computer application may be used to teach urology to undergraduate medical students.

Methods. Third-year medical students rotating on their urology clerkship were studied. Student knowledge was measured with a multiple choice test administered in a pretest–post-test experimental design. The educational intervention was a multimedia-based application that presented a clinical module on hematuria, using natural language-like entries. Student attitudes toward the multimedia application were assessed by a survey.

Results. Twenty-three consecutive third-year medical students participated. Mean pretest and post-test scores ± standard deviation were 35% ± 11% versus 74% ± 17%, respectively, P < 0.0001. Student questionnaire responses indicated highly positive opinions that the multimedia-based module was easy to use, was fun, provided natural patient responses, had clear exercises, provided immediate feedback, was educational, and had a nonthreatening format, and that the multiple choice questions were clear and fair.

Conclusions. Multimedia-based education may be used to teach urology to undergraduate medical students.