Remission of psoriasis after treatment with interferon-alfa and 2-chlordeoxyadenosine for hairy cell leukemia - 07/09/11
Abstract |
2-Chlordeoxyadenosine (2-CdA) is an antineoplastic/immunosuppressive agent used to treat hairy cell leukemia (HCL), chronic lymphocytic leukemia, and low-grade lymphomas. Its immunomodulatory properties, however, may allow its future use in the treatment of psoriasis. We report a patient with psoriasis and HCL who was treated for 1 week with continuous intravenous infusion of 2-CdA for recurring HCL. Both the psoriasis and the HCL cleared. Four years after 2-CdA treatment, the patient has psoriasis on only 1% of his body surface area. 2-CdA induces lymphocytopenia, which may explain the improvement in this patient’s psoriasis. (J Am Acad Dermatol 1999;40:316-8.)
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This supplement is made possible through an educational grant from Ortho Dermatological to the American Academy of Dermatology. |
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From the University of Pittsburgh School of Medicine,a and Clinical Medicineb and Department of Dermatology,c University of Pittsburgh Medical Center. |
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Reprint requests to: Mark P. Seraly, MD, 190 Lothrop St, Suite 145, Pittsburgh, PA 15213. E-mail: seralymp@MSX.UPMC.EDU |
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0190-9622/99/$8.00 + 0 16/4/97653 |
Vol 41 - N° 2S
P. 316-318 - août 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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