Dural sinus thrombosis (DST) is a term that encompasses thrombosis of cortical and deep cerebral veins and the dural sinuses. The thrombosis of the cerebral venous system prevents normal drainage of blood and thus causes venous hypertension, increased intracranial pressure, and subsequent hemorrhagic infarction. Because it is a relatively rare problem and its presentation is often nonspecific, the diagnosis is frequently delayed or missed. Although there is a lack of true incidence and prevalence data, it is agreed that with the advent of better diagnostic tools, the diagnosis is made with increasing frequency. Antithrombotic agents and systemic thrombolytic agents have been used with variable success. Recent advances in endovascular techniques allow local infusion of thrombolytic agents in the treatment of DST with success.