FUTURE DIRECTIONS WITH TAXANE THERAPY - 08/09/11
Résumé |
The taxanes, a new class of antitumor agents, act by preventing microtubule disassembly. They are found in nature in many different plant species and fungi. Paclitaxel is a natural taxane extracted from the bark of Taxus brevifolia, and docetaxel is a semisynthetic derivative of Taxus baccata, which differs from paclitaxel by a OC(CH3)3 moiety rather than a benzamide phenyl group on the C-13 side chain, and a hydroxy group, rather than an acetyl group at position 10. Paclitaxel is formulated in polyoxyethylated castor oil (Cremophor EL, Bristol Myers Squibb, Princeton, NJ), and docetaxel in polysorbate 80. In vitro, taxanes at a concentration as low as 0.05 μM bind preferentially to microtubules, inducing metaphase arrest and apoptotic death in a few days. Docetaxel may be more potent than paclitaxel in promoting microtubule assembly.66
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| Address reprint requests to Gisele Sarosy, MD, Medical Ovarian Cancer Section, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Building 82, Room 113, 9030 Old Georgetown Road, Bethesda, MD 20892 |
Vol 13 - N° 1
P. 21-41 - février 1999 Retour au numéro
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