CHEMICAL AND PHYSIOLOGIC BRAIN IMAGING IN SCHIZOPHRENIA - 08/09/11
Résumé |
Past and ongoing neuroimaging studies have identified morphologic brain changes in schizophrenia and noninvasive magnetic resonance spectroscopy (MRS) studies have identified changes in living brain chemistry and molecular composition in schizophrenia. Functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and single-photon emission-computed tomography (SPECT) functional-imaging studies have identified abnormal physiological indices in schizophrenia related to cerebral blood flow (CBF) and uptake of labeled 2-deoxyglucose. PET receptor studies have been equivocal regarding changes in the number of D2 dopamine receptors in schizophrenia, but have provided insights into in vivo brain receptor occupancy for both typical and atypical antipsychotics. These studies provide exciting and informative insights into schizophrenia. These insights, taken together, pose the following questions:
1 | Do the morphologic changes precede and produce chemical and physiologic changes, or do chemical and physiologic changes precede morphologic changes and produce them? |
2 | Does abnormal morphometrics always produce abnormal chemical and physiologic indices? |
3 | Can there be abnormal chemical and physiologic findings with normal morphometrics? |
4 | Can there be abnormal behavioral findings with normal chemical and physiologic findings? |
5 | Do the chemical and the physiologic findings correlate with morphometric findings? |
6 | Do the chemical and the physiologic findings correlate with behavioral findings? |
Technologic advances in the preceding imaging techniques in the past few years present the opportunity to understand the neuropathology of schizophrenia and to begin to answer these questions.
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| Address reprint requests to Jay W. Pettegrew, MD, Room A741 Crabtree Hall/GSPH, 130 DeSoto Street, University of Pittsburgh, PA 15213 This work was supported in part by National Institutes of Mental Health grants, 46614, 01180, 45203, and 45156; an NINDS grant NS-3355; and NIA grant AG-08974, and a Scottish Rite Research Foundation Grant. |
Vol 21 - N° 1
P. 93-122 - mars 1998 Retour au numéro
Article précédent
- STRUCTURAL BRAIN IMAGING IN SCHIZOPHRENIA
- Peter F. Buckley
- NEURODEVELOPMENTAL AND NEUROPROGRESSIVE PROCESSES IN SCHIZOPHRENIA : Antithetical or Complementary, Over a Lifetime Trajectory of Disease?
- John L. Waddington, Abbie Lane, Paul J. Scully, Conall Larkin, Eadbhard O'Callaghan
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