Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure - 09/09/11
Doi : 10.1016/S0022-3476(98)70312-9
Abstract |
We prospectively analyzed airway specimens from 24 newborn infants. Inhaled nitric oxide (≤20 ppm for 1 to 4 days to 12 infants) did not affect the concentrations of the lipid peroxidation product, the surface activity, or the cytokines (interleukin-1, granulocyte-macrophage colony-stimulating factor, interleukin-1 receptor antagonist). Nitrotyrosine was detected after 10 days of life in the two infants requiring prolonged ventilation, suggesting toxicity of endogenous nitric oxide. (J Pediatr 1998;132:827-9)
Le texte complet de cet article est disponible en PDF.Abbreviations : IL-1, IL-1ra, NO, NO2, PPHN
Plan
 | From the Department of Pediatrics, Division of Neonatal Medicine, University of California, Irvine Medical Center, Orange, California; the Department of Pediatrics, University of Oulu, Oulu, Finland; the Department of Pediatrics, Division of Neonatal Medicine, Vanderbilt University, Nashville, Tennessee; and Sierra Vista Regional Medical Center, San Luis Obispo, California |
| Supported in part by the Foundation for Maternal and Infant Care. |
 | Reprint requests: Mikko Hallman, MD, Department of Pediatrics, University of Oulu, Kajaanintie 52 A, 90220 Oulu, Finland. |
| 0022-3476/98/$5.00 + 0 9/21/86319 |
© 1998
Mosby, Inc. Tous droits réservés.
Vol 132 - N° 5
P. 827-829 - mai 1998 Retour au numéro
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