L-selectin expression on polymorphonuclear leukocytes and monocytes in premature infants: Reduced expression after dexamethasone treatment for bronchopulmonary dysplasia - 09/09/11
Abstract |
We examined the effect of dexamethasone on the expression of the adhesion molecule L-selectin on circulating polymorphonuclear leukocytes (PMLs) and monocytes from premature infants with bronchopulmonary dysplasia (BPD). Nineteen infants who received dexamethasone (Dex group) and 28 who did not receive dexamethasone (no Dex group) were studied. L-selectin expression, measured as mean fluorescence intensity, was lower on circulating PMLs (5.7 ± 0.6 vs 10.6 ± 0.7, p < 0.001) and monocytes (7.9 ± 0.9 vs 12.5 ± 0.9, p < 0.02) isolated from those who had received dexamethasone. Because L-selectin is important for the recruitment of PMLs to inflammatory foci in the lungs, we speculate that one of the mechanisms by which dexamethasone reduces inflammation in BPD is by impairing the ability of leukocytes to migrate into the BPD lesions. (J Pediatr 1998;132:53-6)
Le texte complet de cet article est disponible en PDF.Abbreviations : BPD, Dex, PMLs, WBCs
Plan
 | From the Department of Pediatrics and Department of Pathology, BC Children's Hospital; Pulmonary Research Laboratory and Department of Pathology and Laboratory Medicine, St Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Supported in part by the British Columbia Lung Association, the Medical Research Council of Canada, and the South African Medical Research Council. |
| Reprint requests: Gregory P. Bondy, MD, Pulmonary Research Laboratory, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, Canada V6Z 1Y6. |
 | 9/21/82216 |
Vol 132 - N° 1
P. 53-56 - janvier 1998 Retour au numéro
Article précédent
- The effect of early dexamethasone administration on bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome
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- Evaluation of criteria for chronic lung disease in surviving very low birth weight infants
- Mari Palta, Mona Sadek, Jodi H. Barnet, Michael Evans, Marie R. Weinstein, Gail McGuinness, Mary Ellen Peters, Debra Gabbert, Dennis Fryback, Philip Farrell, for the Newborn Lung Project*
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