Urethritis represents a common manifestation of sexually transmitted infection and the most common reason for male patients with a sexually transmitted disease (STD) to present to STD clinics or to private physicians. The clinical syndrome typically manifests with mucoid or purulent urethral discharge; burning upon urination may also be present. The urethra in women can also become infected with the sexually transmitted pathogens that cause urethritis, but the focus of this article is the male patient. This article discusses management of the treatable pathogens causing urethritis, with a focus on the 1998 STD Treatment Guidelines from the Centers for Disease Control and Prevention (CDC).