THYROTOXICOSIS IN CHILDREN - 09/09/11
Résumé |
The association of goiter and exophthalmos was first recorded in a legal Byzantine text from the third century in which a “man with bulging eyes and a great walnut round the neck” was described. 75 The recognition of the disease known as exophthalmic goiter is attributed, however, to Parry. 24, 87 In 1786 he observed a female patient with palpitations, cardiac enlargement, thyromegaly, and “eyes that were protruded from their sockets.” His record of six cases was not published until 1825, 3 years after his death. Similar patients with “thyroid enlargement,” “unnatural excitement,” “lids that were incapable of closing,” and “eyeballs that were pushed wide from one another and could not be closed” were reported in 1835 by Graves and in 1840 by Von Basedow. 24, 38 In 1909 Osler was the first to hypothesize that the symptoms of Graves' disease were caused by the hypersecretion of certain materials by the thyroid gland. Graves' disease still accounts for most cases of hyperthyroidism in children and adolescents. This review also discusses the less common forms of thyrotoxicosis in the pediatric age group. These rare causes of hyperthyroidism are important to recognize so that proper specific management can be instituted.
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| Address reprint requests to Donald Zimmerman, MD, Division of Pediatric Endocrinology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 |
Vol 27 - N° 1
P. 109-126 - mars 1998 Retour au numéro
Article précédent
- SUPPORT GROUPS FOR PATIENTS WITH GRAVES' DISEASE AND OTHER THYROID CONDITIONS
- Lawrence C. Wood
- HYPERTHYROIDISM IN PREGNANCY
- Jorge H. Mestman
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