SEPTIC SHOCK - 10/09/11

Doi : 10.1016/S0749-0704(05)70328-6

Joseph A. Carcillo, MD ^a, Robert E. Cunnion, MD ^b

^a Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Pittsburgh, and University of Pittsburgh Medical School, Pittsburgh, Pennsylvania (JAC);

^b the Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland (REC)

Résumé

In 1963, before the advent of critical care medicine, a study of 900 infants at the University of Minnesota reported a 97% mortality rate with gram-negative sepsis and septic shock.^{34 Dupont H.L., Spink W.W. Infections due to gram negative organisms: An analysis of 860 patients with bacteremia at the University of Minnesota Medical Center, 1958–1966 Medicine 1969 ; 48 : 507

Cliquez ici pour aller à la section Références} In 1992, the J-5 antibody and HA-1A endotoxin antibody trial for pediatric sepsis and septic shock reported an approximate 20% to 25% mortality rate for children (Centocor, personal communication, 1993).^{3 Anonymous Treatment of severe infectious purpura in children with human plasma from donors immunized with Escherichia coli J5: A prospective double blind study J Infect Dis 1992 ; 165 : 695

Cliquez ici pour aller à la section Références} In 1993, a multicenter trial of corticosteroids for pediatric sepsis in three African hospitals showed an approximate 10% mortality rate for children in the experimental and the placebo control groups (American Academy of Pediatrics meeting, critical care section). In 1996, a single institution study of 100 children with sepsis-induced organ failure showed a 15% overall mortality rate.^{32 Doughty L.A., Kaplan S.S., Carcillo J.A. Inflammation and outcome in pediatric sepsis induced multiple organ failure San Diego, CA: Society for Critical Care Medicine Symposium (1997).

Cliquez ici pour aller à la section Références} Despite these remarkable improvements in outcome, sepsis and septic shock remain an important cause of morbidity and mortality in neonates and children.^{53 Jacobs R.F., Sowell M.K., Moss M.M. , et al. Septic shock in children: Bacterial etiologies and temporal relationships Pediatr Infect Dis J 1990 ; 9 : 196 [cross-ref]

Cliquez ici pour aller à la section Références, 76 Naqvi J.H., Chundu K.R., Friedman A.D. Shock in children with gram negative bacillary sepsis and Haemophilus influenzae type B sepsis Pediatr Infect Dis 1986 ; 5 : 512 [cross-ref]

Cliquez ici pour aller à la section Références, 96 Proulx F., Fayon M., Farrell C.A. , et al. Epidemiology of sepsis and multiple organ dysfunction syndrome in children Chest 1996 ; 109 : 1033 [cross-ref]

Cliquez ici pour aller à la section Références}

Le texte complet de cet article est disponible en PDF.

Plan

PEDIATRIC SEPSIS

Pathogenesis

Factors Predisposing to Sepsis and Septic Shock

Prevention

Early Recognition of Pediatric Sepsis

Immediate Resuscitation (The first hour)

Stabilization of Sepsis and Septic Shock (After the first hour of resuscitation)

ADULT SEPSIS

Pathogenesis

Predisposing Factors and Prevention

Early Recognition

Immediate Resuscitation

Stabilization of Sepsis and Septic Shock

Address reprint requests to Joseph A. Carcillo, MD, Division of Pediatric Critical Care, Children's Hospital of Pittsburgh, 3705 5th Avenue, Pittsburgh, PA 15213

Export

Vol 13 - N° 3

P. 553-574 - juillet 1997 Retour au numéro

Article précédent

ACUTE RESPIRATORY FAILURE IN THE HIV-SEROPOSITIVE PATIENT
Mark J. Cowan, James H. Shelhamer, Stewart J. Levine

| Article suivant

ACUTE RENAL FAILURE IN INFANTS, CHILDREN, AND ADULTS
Charles L. Stewart, Richard Barnett

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

SEPTIC SHOCK - 10/09/11

Résumé

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL