Preterm lung function after retreatment with antenatal betamethasone in preterm lambs - 10/09/11
Abstract |
OBJECTIVE: We hypothesized that two doses of betamethasone administered 1 week apart would further enhance postnatal pulmonary function in preterm lambs (compared with a single dose).
STUDY DESIGN: Fetal sheep (121 days' gestation) randomly received saline solution or betamethasone (0.5 mg/kg) as a single injection. Six days later fetal sheep were retreated with either saline solution or corticosteroid, and postnatal lung function was evaluated 1 day later.
RESULTS: Betamethasone improved compliance and ventilation efficiency index nearly 50%, and total lung volume increased twofold. No effects of treatment-to-delivery interval (1 vs 7 days) or corticosteroid retreatment on pulmonary function were apparent. Although surfactant pool sizes increased as a function of duration of exposure, no additional effect of corticosteroid retreatment was noted. Antenatal betamethasone increased messenger ribonucleic acid levels for the surfactant proteins A and C, and retreatment augmented surfactant protein B messenger ribonucleic acid levels but suppressed surfactant protein A and C messenger ribonucleic acid.
CONCLUSION: Improved postnatal lung function resulting from antenatal betamethasone was not augmented by retreatment. (Am J Obstet Gynecol 1997;176:308-15.)
Le texte complet de cet article est disponible en PDF.Keywords : Lung maturation, corticosteroids, surfactant proteins, surfactant, respiratory distress syndrome
Plan
 | From the Perinatal Research Laboratories, Harbor–University of California, Los Angeles, Medical Center,a the Institute for Child Health Research,b and King Edward Memorial Hospital.c |
| Supported by grant No. HD-20618 from the U.S. Public Health Service, National Institutes of Health. |
 | Reprint requests: Machiko Ikegami, MD, PhD, Perinatal Research Laboratories, Harbor–University of California, Los Angeles, Medical Center, 1124 W. Carson St., RB-1, Torrance, CA 90502. |
| 0002-9378/97 $5.00 + 0 6/1/77895 |
Vol 176 - N° 2
P. 308-315 - février 1997 Retour au numéro
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