Preeclampsia is associated with a reduced response to activated protein C - 10/09/11
Abstract |
OBJECTIVE: Resistance to activated protein C is an inherited mutation of the coagulation factor V gene, a major factor predisposing to thromboembolic events. The purpose of this study was to investigate the occurrence of heterozygote and homozygote activated protein C resistance in women with preeclampsia.
STUDY DESIGN: Activated protein C resistance and protein C and antithrombin III levels were determined in women (n = 50) with a history of preeclampsia and in controls (50 women with a previous normal pregnancy). The mutation of the factor V gene was analyzed.
RESULTS: Activated protein C resistance was found in 22% of women with previous preeclampsia compared with 10% among controls. Two women in the previous preeclampsia group had a homozygote mutation of factor V; the others were heterozygous. There was a significant difference in the activated protein C ratio between women with previous preeclampsia and the control group, 2.6 ± 0.4 versus 3.1 ± 0.5 (p = 0.04). None of the women had protein C or antithrombin III deficiency.
CONCLUSION: The results indicate that activated protein C resistance may be a contributory factor in the pathogenesis of preeclampsia.(Am J Obstet Gynecol 1997;176:457-60.)
Le texte complet de cet article est disponible en PDF.Keywords : coagulation, protein C, pregnancy, preeclampsia
Plan
 | From the Departments of Obstetrics and Gynecologya and Medicine,b University of Lund, University Hospital. |
| Supported by Swedish Medical Research Council grant No. 04523, the Swedish Medical Society, and the Medical Faculty, University of Lund, Sweden. |
 | Reprint requests: Claes Lindoff, MD, PhD, Department of Obstetrics and Gynecology, University of Lund, University Hospital, S-221 85 Lund, Sweden. |
| 6/1/78403 |
Vol 176 - N° 2
P. 457-460 - février 1997 Retour au numéro
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