Effect of maternal CD4 + cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection - 11/09/11
Abstract |
Among a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers, we correlated infant outcome with maternal CD4 + lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infant outcome with maternal quantitative viral burden as measured by the nucleic acid sequence based amplification system. We found that low maternal CD4 + cell count and high viral burden were associated with decreased time to category C disease or death in infants infected with human immunodeficiency virus type 1. In a multivariate analysis, high maternal viral load and maternal acquired immunodeficiency syndrome were independently associated with shorter time to category C disease or death in infants with human immunodeficiency virus type 1 infection. High viral load in pregnant women, independent of the presence of advanced maternal disease, appears to increase the risk of rapidly progressive disease in their infected offspring. (J Pediatr 1997;130:830-7)
Le texte complet de cet article est disponible en PDF.Abbreviations : AIDS, CDC, CI, HIV-1, PCR, RNA, VL, ZDV
Plan
 | The New York City Perinatal HIV Transmission Collaborative Study Group are listed in the Appendix. |
| 0022-3476/97/$5.00 + 0 9/21/78629 |
 | Supported in part by cooperative agreement No. U64 CCU 200937 with the Centers for Disease Control and Prevention through a grant to the Medical and Health Research Association of New York City, Inc. |
| Reprint requests: Genevieve Lambert, MD, Bronx Lebanon Hospital Center, Milstein 10C, 1650 Selwyn Ave., Bronx, NY 10457. |
Vol 130 - N° 6
P. 890-897 - juin 1997 Retour au numéro
Article précédent
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