Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome - 11/09/11
From the Department of Molecular Medicine, University of Auckland, New Zealand, and the Division of Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland.
Abstract |
We examined T-cell proliferation in five patients with X-linked hyper-IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii. (J Pediatr 1997;131:147-50)
Le texte complet de cet article est disponible en PDF.Abbreviations : ConA, PBMC, PHA, XHIM
Plan
 | Now at the Genesis Corporation,Auckland, New Zealand. |
| Supported by the New Zealand Arthritis Foundation, the Rose Hellaby trust, the Kirsty McDermott trust, the Ruth Spencer trust, and the Auckland Medical Research Foundation, Dr, Ochs is supported by National Institutes of Health grant HD17427, and part of this work was conducted through the clinical research center of the University of Washington (National Institutes of Health grant RR37). |
 | Reprint requests: Rohan Ameratunga, FRACP, FRCPA, CMSC 1102, Division of Immunology, Johns Hopkins Hospital, Baltimore MD 21287. |
| 0022-3476/97/$5.00 + 0 9/22/79480 |
Vol 131 - N° 1
P. 147-150 - juillet 1997 Retour au numéro
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