BONE MARROW METASTASES - 11/09/11

Doi : 10.1016/S0889-8588(05)70341-5

Elizabeth J. Shpall, MD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Adrian P. Gee, PhD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Christopher Hogan, PhD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Pablo Cagnoni, MD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Ursula Gehling, MD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Lisa Hami, MT ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Wilbur Franklin, MD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Scott I. Bearman, MD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Maureen Ross, MD, PhD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}, Roy B. Jones, PhD, MD ^{^{*
From the Bone Marrow Transplant Program (EJS, CH, PC, UG, LH, SIB, MR, RBJ) and the Department of Pathology (WF), University of Colorado, Denver, Colorado; and the Division of Transplantation Medicine, Richland Memorial Hospital and the University of South Carolina, Columbia, South Carolina (APG)}}

Plan

THE CLINICAL SIGNIFICANCE OF MARROW METASTASES

Clinical Course

Correlation Between Marrow Metastases and Clinical Outcome in the Standard Therapy Setting

The Clinical Impact of Marrow Metastases in the Autologous Transplant Setting

METHODS FOR CANCER CELL DETECTION IN BONE MARROW

Routine Detection Methods

Sensitive Detection Methods

METHODS FOR ERADICATING CANCER CELLS FROM MARROW

Negative Purging Methods

Positive Selection Methods for Elimination of Tumor Cells

THE CLINICAL IMPACT OF MARROW PURGING AND PURIFICATION IN THE AUTOLOGOUS TRANSPLANT SETTING

Acute Myelogenous Leukemia (AML)

Non-Hodgkin's Lymphoma

Breast Cancer

CONCLUSION

Address reprint requests to Elizabeth J. Shpall, MD University of Colorado Health Sciences Center Campus Box B190 4200 East Ninth Avenue Denver, CO 80262