Pediatric clozapine intoxication - 11/09/11
, Paul Wax, MD , David Wang, MD †, Carla Goetz, PharmD ‡, Carmen Hadley §, Raymond Love ‡ From the Department of Emergency Medicine, University of Rochester USA Abstract |
Clozapine is a tricyclic dibenzodiazepine derivative used as an antipsychotic in adults. Clozapine's safety in children has not been established. This report describes three unintentional clozapine ingestions in pediatric patients. These are the first reported cases of clozapine intoxication in children. All three patients demonstrated dramatic alterations in mental status and tone, and two demonstrated extrapyramidal effects. Serum clozapine levels obtained in two patients were within the average range of steady state plasma concentrations for adults. These cases show the dramatic presentations of pediatric ingestion of clozapine and the differences between adult and pediatric intoxications.
Le texte complet de cet article est disponible en PDF.Keywords : Pediatric, clozapine, ingestion, intoxication, antipsychotic, overdose, Clozaril, extrapyramidal symptoms, altered mental status
 | Presented at the 1993 International Congress of Clinical Toxicology, September 12, 1993, as three separate cases. |
Vol 14 - N° 5
P. 462-463 - septembre 1996 Retour au numéro
Article précédent
- Massive verapamil overdose complicated by noncardiogenic pulmonary edema
- Barry J Brass, Sherma Winchester-Penny, Bennet L Lipper
- Encephalopathy and cranial nerve palsies caused by intentional trichloroethylene inhalation
- C.Stephen Szlatenyi, Richard Y Wang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?