Colonization with group B streptococci in pregnancy and adverse outcome - 11/09/11
For the VIP Study Group
Abstract |
OBJECTIVE: Our purpose was to study the association of cervicovaginal colonization with group B streptococci with pregnancy and neonatal outcome. STUDY DESIGN: A prospective study was conducted at seven medical centers between 1984 and 1989. Genital tract cultures were obtained at 23 to 26 weeks' gestation and at delivery. Prematurity and neonatal sepsis rates were compared between group B streptococci positive and negative women. RESULTS: Group B streptococci was recovered from 2877 (21%) of 13,646 women at enrollment. Heavy colonization was associated with a significant risk of delivering a preterm infant who had a low birth weight (odds ratio = 1.5, 95% confidence interval 1.1 to 1.9). Heavily colonized women given antibiotics effective against group B streptococci had little increased risk of a preterm, low-birth-weight birth. Women with light colonization were at the same risk of adverse outcome as the uncolonized women. Neonatal group B streptococci sepsis occurred in 2.6 of 1000 live births in women with and 1.6 of 1000 live births in women without group B streptococci at 23 to 26 weeks' gestation ( p = 0.11). However, sepsis occurred in 16 of 1000 live births to women with and 0.4 of 1000 live births to women without group B streptococci at delivery ( p < 0.001). CONCLUSIONS: Heavy group B streptococci colonization at 23 to 26 weeks' gestation was associated with an increased risk of delivering a preterm, low-birth-weight infant. Cervicovaginal colonization with group B streptococci at 23 to 26 weeks' gestation was not a reliable predictor of neonatal group B streptococci sepsis. Colonization at delivery was associated with sepsis. (AM J OBSTET GYNECOL 1996;174:1354-60.)
Le texte complet de cet article est disponible en PDF.Keywords : Group B streptococci, Streptococcus agalactiae, low birth weight, preterm birth
Plan
| ☆ | From the Department of Pediatrics, Columbia University,athe National Institute of Child Health and Human Development, National Institutes of Health,bthe Department of Obstetrics and Gynecology, University of Washington,cthe National Institute of Allergy and Infectious Diseases, National Institutes of Health,dthe Research Triangle Institute,ethe Department of Obstetrics and Gynecology, University of Texas,fthe Department of Pediatrics, University of Oklahoma,gand the Department of Medicine, Louisiana State University.h |
| ☆☆ | Supported by contracts HD-3-2832 through HD-3-2836 and AI-4-2532 from the National Institutes of Health. |
| ★ | Reprint requests: Mark A. Klebanoff, MD, DESPR, NICHD, NIH, 6100 Bldg., Room 7B03; Bethesda, MD 20892. |
| ★★ | 6/1/69379 |
Vol 174 - N° 4
P. 1354-1360 - avril 1996 Retour au numéro
Article précédent
- Pregnancy outcomes in the Diabetes Control and Complications Trial
- The Diabetes Control Complications Trial Research Group, A complete listing of members of the Diabetes Control and Complications Trial Research Group is available in Arch Ophthalmol 1995;113:4951.
- Differences in practice patterns between obstetricians and family physicians: Use of serum screening
- Jerome Yankowitz, Donald M. Howser, John W. Ely
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?