Corticotropin-releasing factor and its binding protein: Maternal serum levels in term and preterm deliveries - 12/09/11
Abstract |
OBJECTIVE: The primary objective of this investigation was to evaluate whether maternal serum corticotropin-releasing factor levels during pregnancy were predictive of spontaneous preterm delivery. STUDY DESIGN: Maternal serum levels of corticotropin-releasing factor and its binding protein were measured from 20 weeks of gestation in a cross-sectional study of 396 asymptomatic women at high risk for preterm delivery. RESULTS: Gestational age–specific corticotropin-releasing factor levels were not consistently or substantially increased for preterm compared with term deliveries, whether preterm delivery was due to preterm labor or preterm premature rupture of membranes. The binding protein for corticotropin-releasing factor did not vary according to gestational age until term, when it dropped substantially. CONCLUSION: Serum corticotropin-releasing factor levels do not appear to be an important predictor of preterm birth in asymptomatic patients who subsequently have either preterm labor or preterm premature rupture of membranes. Nevertheless, the drop in the corticotropin-releasing factor binding protein level at term suggests that the bioavailability of corticotropin-releasing factor increases as parturition approaches. (AM J OBSTET GYNECOL 1996;174:1477-83.)
Le texte complet de cet article est disponible en PDF.Keywords : Corticotropin-releasing factor, preterm labor, premature rupture of membranes
Plan
| ☆ | From the Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine,athe Department of Obstetrics and Gynecology, New York University Medical Center,bthe Department of Obstetrics and Gynecology, University of Pisa,cand the Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention.d |
| ☆☆ | Supported in part by Cooperative Agreement No. U501CCU300860-09 with the Association of Teachers of Preventive Medicine and Centers for Disease Control and Prevention and by the Italian Research Council targeted project “Prevention and Control of Disease Factors,” subproject “:Maternal Infant Diseases,”: contract No. 94.00631.PF41. |
| ★ | Reprints not available from the authors. |
| ★★ | 6/1/70205 |
Vol 174 - N° 5
P. 1477-1483 - mai 1996 Retour au numéro
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