Comparative effectiveness of radial probe endobronchial ultrasound versus CT-guided needle biopsy for evaluation of peripheral pulmonary lesions: A randomized pragmatic trial - 17/09/11
, Janette Vincent c , Stefan Heinze c , Phillip Antippa d , Louis B. Irving a 
Corresponding author. Department of Respiratory Medicine, Level 1, Centre for Medical Research, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia. Tel.: +61 3 9342 7708; fax: +61 3 8610 1687.Summary |
In many patients the optimal method of investigation of peripheral pulmonary lesions (PPL) is not clear. We performed a prospective randomized pragmatic trial to determine the comparative effectiveness of endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) and CT-guided percutaneous needle biopsy (CT-PNB) for the investigation of PPL. Overall complication rates were higher in those undergoing CT-PNB (27% v 3%, p = 0.03), while diagnostic accuracy of EBUS-TBLB was shown to be non-inferior to that of CT-PNB.
Expected diagnostic accuracy and complication rates are likely to differ for individual patients on the basis of specific complex clinicoradiologic factors, which will influence the cost-benefit analysis between EBUS-TBLB and CT-PNB for individual patients. Further studies are required to examine the effect of these factors on clinical decision-making.
Le texte complet de cet article est disponible en PDF.Keywords : Bronchoscopy, Diagnostic accuracy, Lung cancer, Non-inferiority, Pneumothorax
Plan
Vol 105 - N° 11
P. 1704-1711 - novembre 2011 Retour au numéro
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