Clinical Trials in Mechanical Circulatory Support - 17/09/11
Corresponding author. Division of Cardiology, Duke University Medical Center, Box 3034 DUMC, Durham, NC 27710.Résumé |
Recent advances in mechanically assisted circulation, including refinement of patient selection criteria and enhancements in device design, have been associated with improvements in survival, functionality and quality of life as well as reductions in adverse events. Novel and innovative trial design, methodology and endpoints have been utilized in the development of the cumulative database supporting the role of ventricular assist devices for the management of patients with advanced heart failure. The rapid and significant improvements in patient-centric outcomes support the expansion of this technology into less moribund populations where the potential benefits may be even more robust.
Le texte complet de cet article est disponible en PDF.Keywords : Mechanical circulatory support, Left ventricular assist device, Bridge to transplant, Destination therapy, Objective performance criteria
Plan
| Funding support: None. |
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| Financial disclosures: JGR, Thoratec, Consultant/Advisory Board, less than $10,000; CAM and GE, none. |
Vol 7 - N° 4
P. 457-466 - octobre 2011 Retour au numéro
Article précédent
- Lessons Learned from Clinical Trials in Acute Heart Failure: Phase 3 Drug Trials
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