Genetics and phenotyping in chronic sinusitis - 30/09/11
, John W. Steinke, PhD a
Corresponding author: Larry Borish, MD, Asthma and Allergic Disease Center, Box 801355, Charlottesville, VA 22903.Abstract |
Chronic sinusitis with nasal polyposis historically has been treated as a single monolithic clinical disorder. Just as asthma is now accepted as numerous heterogeneous diseases, chronic sinusitis should also be viewed as comprising several diseases with varying causes, with each one characterized by distinct histologic and gene and protein expression patterns. This includes recognition of the need to define these diseases based on the presence or absence of an eosinophilic infiltrate but also on additional distinctions based on unique agents that drive their development and perpetuation. As a collection of heterogeneous diseases, proper differential diagnosis is required to delineate appropriate therapeutic intervention. This review will focus on recognized distinct presentations of chronic sinus disease, including distinguishing the clinical presentations, cellular and molecular characteristics, genetic differences, and current treatment options for each.
Le texte complet de cet article est disponible en PDF.Key words : Fibrosis, chronic sinusitis, aspirin-exacerbated respiratory disease, eosinophils, nasal polyps
Abbreviations used : AERD, AFS, CCS, CF, CHES, CS, CT, CysLT, HIF, LTC4S, NES, NP, PAI-1, PG
Plan
| Series editors: Joshua A. Boyce, MD, Fred Finkelman, MD, William T. Shearer, MD, PhD, and Donata Vercelli, MD |
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| Terms in boldface and italics are defined in the glossary on page 711. |
Vol 128 - N° 4
P. 710-720 - octobre 2011 Retour au numéro
Article précédent
- Chronic rhinosinusitis: Epidemiology and medical management
- Genetics and phenotyping in chronic sinusitis
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