Magnetic resonance imaging demonstrates long-term changes in brain structure in children born preterm and exposed to chorioamnionitis - 01/10/11
, Deborah A. Wing, MD a, Claudia Buss, PhD b, c, Kevin Head, BS c, L. Tugan Muftuler, PhD d, Elysia Poggi Davis, PhD b, c
Reprints: Tamera Hatfield, MD, PhD, University of California, Irvine, 101 The City Dr., Bldg. 56, Orange, CA 92868Résumé |
Objective |
We sought to determine if children born preterm and exposed to chorioamnionitis have differences in brain structure measured at 6-10 years of age using magnetic resonance imaging (MRI).
Study Design |
Structural MRI was performed with 11 preterm children (8.5 ± 1.7 years) with chorioamnionitis and 16 preterm children (8.7 ± 1.4 years) without chorioamnionitis. Cortical surface reconstruction and volumetric segmentation were performed with FreeSurfer image analysis software. Subcortical structures were analyzed using multivariate analysis.
Results |
Widespread regional differences in cortical thickness were observed. With chorioamnionitis, the frontal and temporal lobes were primarily affected by decreased cortical thickness, and the limbic, parietal, and occipital lobes were primarily affected by increased cortical thickness when compared to the comparison group. Subcortical differences were observed in the hippocampus and lateral ventricle.
Conclusion |
Using MRI, chorioamnionitis is associated with long-term widespread regional effects on brain development in children born prematurely. Our study is limited by its small sample size.
Le texte complet de cet article est disponible en PDF.Key words : chorioamnionitis, infection, magnetic resonance imaging, neurodevelopment, preterm
Plan
| This report was funded in part by National Institute for Child Health and Human Development R01 HD050662 (E.P.D.). |
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| The authors report no conflict of interest. |
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| Cite this article as: Hatfield T, Wing DA, Buss C, et al. Magnetic resonance imaging demonstrates long-term changes in brain structure in children born preterm and exposed to chorioamnionitis. Am J Obstet Gynecol 2011;205:384.e1-8. |
Vol 205 - N° 4
P. 384.e1-384.e8 - octobre 2011 Retour au numéro
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