Maternal Triglyceride Levels during Early Pregnancy are Associated with Birth Weight and Postnatal Growth - 11/10/11
, Sietske J. Algera, MSc a, b, Ingeborg A. Brouwer, PhD c, Manon van Eijsden, PhD d, Marcel B. Twickler, MD, PhD e, f
Reprint requests: Tanja G. M. Vrijkotte, PhD, Department of Public Health, Academic Medical Centre, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, the Netherlands.Abstract |
Objective |
To investigate whether randomly sampled maternal total cholesterol (TC) and triglycerides (TG) levels during early pregnancy are associated with birth weight (BW) and postnatal growth.
Study design |
Data were derived from the prospective Amsterdam Born Children and their Development cohort study. Randomly sampled TC and TG levels were determined in early gestation (median, 13; IQR, 12-14 weeks). Outcome measures were BW SDS and weight-for-gestational age; postnatal outcome measures were SDS in weight, length, and body mass index during the first year of life (total n = 2502).
Results |
The highest TG level was associated with a higher BW SDS (differences 0.20 ± 0.06 between highest and middle quintile; P = .002) and with a higher prevalence (13%) of an infant large for gestational age compared with middle quintile (9%; P = .04). Infants from mothers in the lowest TG quintile had lower SDS in weight, length, and body mass index until age 3 months, and displayed accelerated postnatal growth patterns. Maternal TC was not associated with BW or postnatal growth.
Conclusion |
High maternal TG levels in the first term of pregnancy were associated with higher BWs and subsequently a higher occurrence of infants large for gestational age, whereas low TG levels were associated with accelerated postnatal growth.
Le texte complet de cet article est disponible en PDF.Mots-clés : ABCD, BMI, BW, LGA, SGA, TC, TG, YHC
Plan
| Supported by the Netherlands Organization for Health Research and Development (ZonMw), The Hague. The authors declare no conflicts of interest. |
Vol 159 - N° 5
P. 736 - novembre 2011 Retour au numéro
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