Pyomyositis is the primary infection of the skeletal muscle. It is common in the tropics, but is increasingly being reported worldwide. It can affect immunocompromised and immunocompetent individuals. Staphylococcus aureus is the most common causative organism. Muscle histology and its culture remain the gold standard for diagnosis. However, among noninvasive methods, MR imaging is highly sensitive and can image large areas of the body and detect subclinical involvement. Early diagnosis, institution of appropriate antibiotic therapy, and drainage of pus lead to favorable outcome.