Unbound Bilirubin does not Increase during Ibuprofen Treatment of Patent Ductus Arteriosus in Preterm Infants - 10/01/12
, Celine Thibaut, MD 1, Yves Kibleur, MD 2, Alexandre Barbier, MD 3, Cecile Bordarier, MD 3, Guy Moriette, MD 3
Reprint requests: Luc Desfrere, MD, Hôpital Louis Mourier, 178 rue des Renouillers, 92700 Colombes, France.Abstract |
Objective |
To determine whether ibuprofen displaces bilirubin from albumin in preterm infants.
Study design |
A total of 34 preterm neonates (<32 weeks gestation) treated by ibuprofen (10-5-5 mg/kg) were included in this prospective open-label study. Total bilirubin (TB), unbound bilirubin (UB), and ibuprofen concentrations were measured before, 1 hour, and 6 hours after the first dose; before and 1 hour after the second dose; and 72 hours after the beginning of treatment. The infants were screened by auditory brainstem responses and by neurologic examination at term.
Results |
At baseline, TB, UB, apparent binding affinity of albumin (Ka), and albumin concentrations were 6.0±1.6 mg/dL, 1.9±2.2 μg/dL, 14.1±5.8 L·μmol−1, and 28.7±2.3 g/L, respectively. Ibuprofen treatment had no effect on TB, UB, or Ka values. No correlation between UB or Ka and ibuprofen concentrations was found. No neurologic symptoms or significant modifications of auditory brainstem responses were observed at term.
Conclusion |
Ibuprofen (10-5-5 mg/kg) did not displace bilirubin in preterm infants with a baseline TB concentration <8.8 mg/dL.
Le texte complet de cet article est disponible en PDF.Mots-clés : ABR, AUC, HsPDA, IV, Ka, MR, PDA, PMA, TB, UB
Plan
| Supported by a grant from Orphan Europe. The authors declare no conflicts of interest. |
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| This trial has been registered at (2004-002458-77), a European clinical trials database. |
Vol 160 - N° 2
P. 258 - février 2012 Retour au numéro
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