Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells - 28/02/12
, Jane M. Turbov, MLS a, Andrew Berchuck, MD c, M. Sharon Stack, PhD d, Jean A. Hurteau, MD a, b, Larry G. Thaete, PhD a, Catherine P. Barry, PhD a
Reprints: Gustavo C. Rodriguez, MD, Division of Gynecologic Oncology, NorthShore University HealthSystem, Walgreen Building, Suite 1507, 2650 Ridge Ave., Evanston, IL 60201Résumé |
Objective |
There is growing evidence that progestins and nonsteroidal antiinflammatory drugs (NSAIDs) may prevent ovarian cancer. Because both induce apoptosis, we investigated the potential for synergistic impact of combined drug treatment on cell death.
Study Design |
Using normal and malignant human ovarian epithelial cells and an NSAID-sensitive human colon cancer cell line, we evaluated the effects of progestins and NSAIDs alone and in combination on apoptosis.
Results |
Both progestins and NSAIDs dose dependently inhibited cell growth (P < .0001). Doses of NSAIDs or progestins that independently reduced cell viability by less than 30% synergistically reduced cell viability by 70-95% when combined. Similarly, the NSAID/progestin combination conferred 4- to 18-fold (P < .05) increased apoptosis over either treatment alone.
Conclusion |
Our results suggest it may be possible to combine progestins and NSAIDs to achieve ovarian cancer prevention at lower doses of each than are required for single administration, thereby lessening the risk of side effects posed by these agents.
Le texte complet de cet article est disponible en PDF.Key words : apoptosis, chemoprevention, nonsteroidal antiinflammatory agents, ovarian neoplasms, progestins
Plan
| This study was supported by in part by the Department of Defense grant OC970003, Bear's Care, and the Hertel-Satter Foundation. |
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| The authors report no conflict of interest. |
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| Cite this article as: Rodriguez GC, Turbov JM, Berchuck A, et al. Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells. Am J Obstet Gynecol 2012;206:253.e1-9. |
Vol 206 - N° 3
P. 253.e1-253.e9 - mars 2012 Retour au numéro
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