Antibiotics nonadherence and knowledge in a community with the world’s leading prevalence of antibiotics resistance: Implications for public health intervention - 29/02/12
, Mandy M. Fan, MBBS, Chun-Man Fok, MBBS, Zara L. Lok, MBBS, Michael Ni, MBBS, Chun-Fung Sin, MBBS, Kwok-Kei Wong, MBBS, Sze-Man Wong, MBBS, Roanna Yeung, MBBS, Terence T. Yeung, MBBS, Wing-Cheong Chow, MBBS, Tai-Hing Lam, MD, C. Mary Schooling, PhD
Address correspondence to Yap-Hang Chan, MBBS, School of Public Health, The University of Hong Kong, 5/F William MW Mong Block, 21 Sassoon Road, Hong Kong.Abstract |
Background |
Community determinants of antibiotics nonadherence, an important contributor of antibiotics resistance, remained unclear.
Objectives |
Our objective was to investigate whether deficient antibiotics knowledge could contribute to nonadherence in a community with high prevalence of antibiotics resistance.
Methods |
We recruited 465 people by random sampling from 5 urban areas in Hong Kong. A structured questionnaire was used to assess antibiotics knowledge and adherence. Adherence was defined as completing the most recent course of antibiotics entirely according to physicians’ instructions. An antibiotics knowledge score ranging from 0 to 3 (highest) was composed based on the number of correctly answered questions.
Results |
Of the 465 participants interviewed, 96.3% had heard of the term “antibiotics,” and 80.6% recalled having previously received antibiotics prescription. Among the eligible 369 subjects, 32.9% showed nonadherence. Percentages of participants with antibiotics knowledge scores of 0, 1, 2, and 3 were 11%, 27%, 33%, and 29%, respectively. There was a higher prevalence of nonadherence among people with lower antibiotics knowledge score (P < .001). Furthermore, people with nonadherence had a significantly lower mean antibiotics knowledge score (1.3 ± 1.0 versus 2.0 ± 0.9, P < .001), with no interaction with education (P < .05). Adjusted for potential confounders, antibiotics knowledge scores of 2, 1, and 0 independently predicted increased risk of nonadherence by 1-fold (odds ratio [OR], 2.00; 95% confidence interval [CI]: 1.01-3.94; P = .047), 4-fold (OR, 4.77; 95% CI: 2.30-9.92; P < .001), and 17-fold (OR, 18.41; 95% CI: 6.92-48.97; P < .001) respectively, compared with the maximum score of 3.
Conclusion |
Lack of antibiotics knowledge is a critical determinant of nonadherence independent of education in the community.
Le texte complet de cet article est disponible en PDF.Key Words : Nonadherence, Antibiotics resistance, Knowledge, Community, Education
Plan
| Conflicts of interest: None to report. |
Vol 40 - N° 2
P. 113-117 - mars 2012 Retour au numéro
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