Progressive Constriction of the Hyperautofluorescent Ring in Retinitis Pigmentosa - 21/03/12
Inquiries to Stephen H. Tsang, Bernard & Shirlee Brown Glaucoma Laboratory, Edward S. Harkness Eye Institute, Columbia University, 160 Fort Washington Ave, Room 513, New York, NY 10032Résumé |
Purpose |
To evaluate the constriction of the hyperautofluorescent ring over time in patients with retinitis pigmentosa (RP).
Design |
Prospective study.
Methods |
Fourteen eyes of 14 RP patients with a hyperautofluorescent ring were studied. Ring constriction was evaluated by measurements of its external and internal boundaries along the vertical and horizontal axes at baseline and at 12-, 24-, 36-, and 48-month follow-ups. Repeat fundus autofluorescence was obtained at 12, 24, 36, and 48 months in 13, 7, 5, and 1 eyes respectively. Spectral-domain optical coherence tomography (SD-OCT) images were obtained on 8 eyes and the horizontal extent of the inner segment/outer segment (IS/OS) junction was measured. SD-OCT was repeated at 12 and 24 months in 6 and 4 eyes respectively.
Results |
The external boundaries of the ring were identified along the horizontal axis in 12 eyes and along the vertical axis in 13. Internal boundaries were identified in 7 eyes. Constriction was demonstrated in all patients except 1 who demonstrated minimal expansion of the internal boundary along the horizontal axis. SD-OCT measurements showed a decrease in the IS/OS junction length.
Conclusion |
Progressive constriction of the hyperautofluorescent ring and a concordant decrease in IS/OS junction length were observed over time.
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| Luiz H. Lima and Chai Lin Chou are now, respectively, in the Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil, and the University of British Columbia, Vancouver, Canada. |
Vol 153 - N° 4
P. 718 - avril 2012 Retour au numéro
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