Internal hypoechoic feature by EUS as a possible predictive marker for the enlargement potential of gastric GI stromal tumors - 21/03/12
Reprint requests: Kazunari Tominaga, MD, PhD, Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka, JapanRésumé |
Background |
There is no clinical predictor for the enlargement potential of gastric GI stromal tumors (GISTs) during the follow-up observation period.
Objective |
The aim of our study was to identify predictive markers for the enlargement potential of gastric GISTs on the basis of various endosonographic features determined at the initial examination.
Design |
Single-center retrospective analysis.
Setting |
Academic university hospital in Japan.
Patients |
All patients (n = 74) with histologically diagnosed GISTs in the stomach underwent EUS.
Intervention |
EUS.
Main Outcome Measurements |
We analyzed the following endoscopic and EUS features: mucosal ulceration, irregular shape, irregular border, heterogeneity, internal hyperechoic spot, hypoechoic area, and anechoic area of gastric GISTs in 3 groups according to tumor size. Furthermore, we compared the characteristics between increased growth and unchanged growth of GISTs, that were defined on the basis of the novel tumor growth index: changes in tumor volume/follow-up interval (days between initial EUS and second EUS) (mm3/day).
Results |
The presence of heterogeneity (P = .016) and anechoic area (P = .003) was significantly highest in the group with the largest tumor size. The increased growth group had a higher presence of hypoechoic area than did the unchanged growth group (84.2% vs 51.9%, P = .023). Multivariate analysis showed that the presence of a hypoechoic area was an enlargement-associated factor (odds ratio 5.38; 95% confidence interval 1.19-24.39; P = .029).
Limitations |
Retrospective design of the study.
Conclusions |
The internal hypoechoic area determined by EUS may be a predictor for the enlargement potential of gastric GISTs.
Le texte complet de cet article est disponible en PDF.Abbreviations : GIST, HPF, MRI
Plan
| DISCLOSURE: T. Tanigawa, K. Watanabe, and T. Arakawa were supported in part by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology in Japan. The following author disclosed financial relationships relevant to this publication: T. Arakawa: advisory committees of Otsuka Pharmaceutical Co., Ltd., and Eisai Co., Ltd. All other authors disclosed no financial relationships relevant to this publication. |
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| If you would like to chat with an author of this article, you may contact Dr Tominaga at tomy@med.osaka-cu.ac.jp. |
Vol 75 - N° 4
P. 731-738 - avril 2012 Retour au numéro
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