Mitochondrial Respiratory Efficiency is Positively Correlated With Human Sperm Motility - 01/04/12
Reprint requests: Dr. Vincenzo Zara, Department of Environmental and Biological Sciences and Technologies, University of Salento, Lecce, ItalyRésumé |
Objective |
To correlate sperm mitochondrial respiratory efficiency with variations in sperm motility and with sperm morphologic anomalies.
Methods |
Sperm mitochondrial respiratory activity was evaluated with a polarographic assay of oxygen consumption carried out in hypotonically-treated sperm cells. A possible relationship among sperm mitochondrial respiratory efficiency, sperm motility, and morphologic anomalies was investigated.
Results |
Mitochondrial respiratory efficiency was positively correlated with sperm motility and negatively correlated with the percentage of immotile spermatozoa. Moreover, midpiece defects impaired mitochondrial functionality.
Conclusion |
Our data indicate that an increase in sperm motility requires a parallel increase in mitochondrial respiratory capacity, thereby supporting the fundamental role played by mitochondrial oxidative phosphorylation in sperm motility of normozoospermic subjects. These results are of physiopathological relevance because they suggest that disturbances of sperm mitochondrial function and of energy production could be responsible for asthenozoospermia.
Le texte complet de cet article est disponible en PDF.Plan
Vol 79 - N° 4
P. 809-814 - avril 2012 Retour au numéro
Article précédent
- Anatomic Site-specific Disparities in Survival Outcomes for Penile Squamous Cell Carcinoma
- Mark D. Tyson, David A. Etzioni, Eric S. Wisenbaugh, Paul E. Andrews, Mitchell R. Humphreys, Robert G. Ferrigni, Scott K. Swanson, Erik P. Castle
- Program for Laparoscopic Urologic Skills: A Newly Developed and Validated Educational Program
- Irene M. Tjiam, Marjolein C. Persoon, Ad J.M. Hendrikx, Arno M.M. Muijtjens, J. Alfred Witjes, Albert J.J.A. Scherpbier
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?