Sleep-Disordered Breathing is Associated with Asthma Severity in Children - 18/04/12
, Amy Storfer-Isser, MS 2, Meeghan A. Hart, MD 1, Anna Marie V. Kibler, MPH 2, Michael Rueschman, MPH 2, 4, Carol L. Rosen, MD 1, Carolyn M. Kercsmar, MD 3, Susan Redline, MD, MPH 2, 4
Reprint requests: Kristie R. Ross, MD, Case Western Reserve University School of Medicine, Division of Pediatric Pulmonology, BRB Room 819, 10900 Euclid Avenue, Cleveland, OH 44106.Abstract |
Objective |
To examine the relationships among obesity, sleep-disordered breathing (SDB, defined as intermittent nocturnal hypoxia and habitual snoring), and asthma severity in children. We hypothesized that obesity and SDB are associated with severe asthma at a 1- year follow-up.
Study design |
Children aged 4-18 years were recruited sequentially from a specialty asthma clinic and underwent physiological, anthropometric, and biochemical assessment at enrollment. Asthma severity was determined after 1 year of follow-up and guideline-based treatment, using a composite measure of level of controller medication, symptom burden, and health care utilization. Multivariate logistic regression was used to examine adjusted associations of SDB and obesity with asthma severity at 12-month follow-up.
Results |
Among 108 subjects (mean age, 9.1±3.4 years; 45.4% African-American; 67.6% male), obesity and SDB were common, affecting 42.6% and 29.6% of subjects, respectively. After adjusting for obesity, race, and sex, children with SDB had a 3.62-fold increased odds of having severe asthma at follow-up (95% CI, 1.26-10.40). Obesity was not associated with asthma severity.
Conclusion |
SDB is a modifiable risk factor for severe asthma after 1 year of specialty asthma care. Further studies are needed to determine whether treating SDB improves asthma morbidity.
Le texte complet de cet article est disponible en PDF.Mots-clés : ACT, BMI, CPAP, ICS, OSA, PSG, SDB
Plan
| Supported by the Cleveland Foundation (grant L2005-0254) and the National Center for Research Resources (grants KL2RR024990, 1 U54 CA116867, M01 RR00080, and UL1 RR024989). The contents are solely the responsibility of the authors and do not necessarily represent the official view of the National Center for Research Resources or the National Institutes of Health. The authors declare no conflicts of interest. |
Vol 160 - N° 5
P. 736-742 - mai 2012 Retour au numéro
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