Injectable drug-eluting elastomeric polymer: a novel submucosal injection material - 21/04/12
Reprint requests: Jian Yang, PhD, Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington, TX 76010-0138Résumé |
Background |
Biodegradable hydrogels can deliver therapeutic payloads with great potentials in EMR and endoscopic submucosal dissection (ESD) to yield improvements in efficacy and foster mucosal regeneration.
Objective |
To assess the efficacy of an injectable drug-eluting elastomeric polymer (iDEEP) as a submucosal injection material.
Design |
Comparative study of 3 different solutions by using material characterization tests and ex vivo and in vivo porcine models.
Setting |
Academic hospital.
Interventions |
Thirty gastric submucosal cushions were achieved with saline solution (0.9%), sodium hyaluronate (0.4%), and iDEEP (n = 10) in ex vivo porcine stomachs. Four porcine gastric submucosal cushions were then created in vivo by using iDEEP.
Main Outcome Measurements |
Maximum injection pressure, rebamipide release rate, submucosal elevation duration, and assessment of in vivo efficacy by en bloc resection.
Results |
No significant difference in injection pressures between iDEEP (28.9 ± 0.3 psi) and sodium hyaluronate (29.5 ± 0.4 psi, P > .05) was observed. iDEEP gels displayed a controlled release of rebamipide up to 2 weeks in vitro. The elevation height of iDEEP (5.7 ± 0.5 mm) was higher than that of saline solution (2.8 ± 0.2 mm, P < .01) and sodium hyaluronate (4.2 ± 0.2 mm, P < .05). All EMR procedures were successfully performed after injection of iDEEP, and a large gel cushion was noted after the resection procedure.
Limitations |
Benchtop, ex vivo, and nonsurvival pig study.
Conclusions |
A novel injection solution was evaluated for endoscopic resection. These results suggest that iDEEP may provide a significant step toward the realization of an ideal EMR and endoscopic submucosal dissection injection material.
Le texte complet de cet article est disponible en PDF.Abbreviations : ESD, iDEEP, PEGMC, SH
Plan
| DISCLOSURE: The authors disclosed no financial relationships relevant to this publication. This work was supported in part by a R21 award (EB009795) (to J.Y.) and a R01 award (1R01EB012575-01A1) (to J.Y.) from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), and a National Science Foundation CAREER award 0954109 (to J.Y.). |
Vol 75 - N° 5
P. 1092-1097 - mai 2012 Retour au numéro
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