Effects on (neuro)developmental and behavioral outcome at 2 years of age of induced labor compared with expectant management in intrauterine growth-restricted infants: long-term outcomes of the DIGITAT trial - 26/04/12
, Kim E. Boers, MD a, Joris A.M. van der Post, MD, PhD b, Maria G. van Pampus, MD, PhD e, Aleid G. van Wassenaer, MD, PhD b, Anneloes L. van Baar, PhD f, Marc E.A. Spaanderdam, MD, PhD h, Jeroen H. Becker, MD g, Anneke Kwee, MD, PhD g, Johannes J. Duvekot, MD, PhD i, Henk A. Bremer, MD, PhD j, Friso M.C. Delemarre, MD, PhD k, Kitty W.M. Bloemenkamp, MD, PhD a, Christianne J.M. de Groot, MD, PhD c, Christine Willekes, MD, PhD l, Frans J.M.E. Roumen, MD, PhD m, Jan M.M. van Lith, MD, PhD a, Ben W.J. Mol, MD, PhD b, n, Saskia le Cessie, PhD a, Sicco A. Scherjon, MD, PhD a, dDIGITAT Study Group
Reprints: Linda van Wyk, MD, Leiden University Medical Center, Department of Obstetrics and Gynecology (K6-27), PO Box 9600, 2300 RC Leiden, The NetherlandsRésumé |
Objective |
We sought to study long-term (neuro)developmental and behavioral outcome of pregnancies complicated by intrauterine growth restriction at term in relation to induction of labor or an expectant management.
Study Design |
Parents of 2-year-old children included in the Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT) answered the Ages and Stages Questionnaire (ASQ) and Child Behavior Checklist (CBCL).
Results |
We approached 582 (89.5%) of 650 parents. The response rate was 50%. Of these children, 27% had an abnormal score on the ASQ and 13% on the CBCL. Results of the ASQ and the CBCL for the 2 policies were comparable. Low birthweight, positive Morbidity Assessment Index score, and admission to intermediate care increased the risk of an abnormal outcome of the ASQ. This effect was not seen for the CBCL.
Conclusion |
In women with intrauterine growth restriction at term, neither a policy of induction of labor nor expectant management affect developmental and behavioral outcome when compared to expectant management.
Le texte complet de cet article est disponible en PDF.Key words : Ages and Stages Questionnaire, Child Behavior Checklist, DIGITAT trial, intrauterine growth restriction, long-term outcome
Plan
| Funded by ZonMw, The Netherlands Organization for Health Research and Development health care efficiency program (grant no. 945-04-558). |
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| The authors report no conflict of interest. |
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| The racing flag logo above indicates that this article was rushed to press for the benefit of the scientific community. |
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| Cite this article as: van Wyk L, Boers KE, van der Post JAM, et al. Effects on (neuro)developmental and behavioral outcome at 2 years of age of induced labor compared with expectant management in intrauterine growth-restricted infants: long-term outcomes of the DIGITAT trial. Am J Obstet Gynecol 2012;206:406.e1-7. |
Vol 206 - N° 5
P. 406.e1-406.e7 - mai 2012 Retour au numéro
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