Narcolepsy - 30/05/12

Doi : 10.1016/j.jsmc.2012.03.013

Sebastiaan Overeem, MD, PhD ^a,^b,^⁎ , Paul Reading, FRCP, PhD ^c, Claudio L. Bassetti, MD ^d,^e
^a Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Centre, Reinier Postlaan 4, PO Box 9101, 6500 HB Nijmegen, The Netherlands
^b Sleep Medicine Centre ‘Kempenhaeghe’, Sterkselseweg 65, 5590 AB Heeze, The Netherlands
^c Department of Neurology, The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, UK
^d Department of Neurology, University Hospital (Inselspital), Freiburgstrasse 1, Bern 3010, Switzerland
^e Neurocenter of Southern Switzerland, Via Tesserete 46, 6903 Lugano, Switzerland

Corresponding author. Department of Neurology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

Résumé

Narcolepsy is widely regarded as the prototypical hypersomnia of central origin. Enormous progress has been made in our understanding of the pathophysiology of the disease, providing additional insights into mechanisms regulating normal sleep and wakefulness. At the same time, it is increasingly recognized that the clinical phenotype of narcolepsy is broad and includes nonsleep symptoms, reflecting metabolic dysfunction and disorders of emotional processing and cognition. This review focuses on the clinical aspects and diagnostic approach toward patients with narcolepsy, emphasizing the severe impact the disease has on daily life.

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Keywords : Narcolepsy, Cataplexy, Hypocretin, Orexin, Excessive daytime sleepiness, Hypersomnia

Plan

	Financial support: Sebastiaan Overeem is supported by a VIDI grant from the Netherlands Organization for Scientific Research (grant number 016.116.371).
	Financial disclosures/conflicts of interest: The authors have nothing to disclose.