P-799 - Effects of the COMT x 5--HTTLPR genetic interaction on brain gray matter volume of healthy individuals - 13/06/12
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 2 |
| Iconographies | 1 |
| Vidéos | 0 |
| Autres | 0 |
Résumé |
Introduction |
Genetic polymorphisms of the catechol-O-methyltransferase gene (COMT Val158Met) and the serotonin transporter linked promoter region (5-HTTLPR) have been reported to influence the gray matter volumes of amygdala and hippocampus, but the studies have been inconsistent.
Aim |
To elucidate the effects of COMT and 5-HTTLPR on regional gray matter volumes in the same sample of healthy individuals.
Methods |
We conducted a diffeomorphic anatomic registration through exponentiated Lie algebra (DARTEL) voxel-based morphometry (VBM) study of the effects of COMT and 5-HTTLPR polymorphisms and their interaction on the gray matter volumes of 91 healthy controls.
Results |
A small increase of gray matter volume in right angular gyrus was detected in carriers of the Met allele of COMT, and no main effects of 5-HTTLPR on gray matter volume were detected. The effects of the interaction between COMT and 5-HTTLPR on gray matter volume were large and mainly involved bilateral amygdala and hippocampus.
[COMT × 5-HTTLPR effects on gray matter volume].
[COMT × 5-HTTLPR effects on gray matter volume].
Conclusions |
The effects of the genetic interaction found in this study might explain the relative inconsistency in the results from previous studies, and suggest further research into genetic interactions.
Le texte complet de cet article est disponible en PDF.Plan
Vol 27 - N° S1
P. 1-2 - 2012 Retour au numéro
Article précédent
- P-798 - Functional connectivity of motor control in attention deficit hyperactivity disorder (ADHD) and pediatric bipolar disorder (PBD) with and without ADHD
- M. Pavuluri, A. Passarotti, J. Ellis, J. Fitzgerald, J. O’Neil, E. Wegbreit
- P-800 - How do antidepressants work? A Positron Emission Tomography (PET) study of brain serotonin levels and affect regulation
- S. Selvaraj, P. Faulkner, E. Mouchlianitis, F. Turkheimer, L. Rosso, J.P. Roiser, P.J. Cowen, O. Howes
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?