Development of innovative techniques for the endoscopic implantation and securing of a novel, wireless, miniature gastrostimulator (with videos) - 20/06/12
Reprint requests: Thomas L. Abell, MD, Professor of Medicine, Director, Division of Digestive Diseases, The University of Mississippi Medical Center, Jackson, MS 39216-4505Résumé |
Background |
Gastric stimulation via high-frequency, low-energy pulses can provide an effective treatment for gastric dysmotility; however, the current commercially available device requires surgical implantation for long-term stimulation and is powered by a nonrechargeable battery.
Objective |
To test and describe endoscopic implantation techniques and testing of stimulation of a novel, wireless, batteryless, gastric electrical stimulation (GES) device.
Design |
Endoscopic gastric implantation techniques were implemented, and in vivo gastric signals were recorded and measured in a non-survival swine model (n = 2; 50-kg animals).
Intervention |
Five novel endoscopic gastric implantation techniques and stimulation of a novel, wireless, batteryless, GES device were tested on a non-survival swine model.
Main Outcome Measurements |
Feasibility of 5 new endoscopic gastric implantation techniques of the novel, miniature, batteryless, wireless GES device while recording and measurement of in vivo gastric signals.
Results |
All 5 of the novel endoscopic techniques permitted insertion and securing of the miniaturized gastrostimulator. By the help of these methods and miniaturization of the gastrostimulator, successful GES could be provided without any surgery. The metallic clip attachment was restricted to the mucosal surface, whereas the prototype tacks, prototype spring coils, percutaneous endoscopic gastrostomy wires/T-tag fasteners, and submucosal pocket endoscopic implantation methods attach the stimulator near transmurally or transmurally to the stomach. They allow more secure device attachment with optimal stimulation depth.
Limitations |
Non-survival pig studies.
Conclusion |
These 5 techniques have the potential to augment the utility of GES as a treatment alternative, to provide an important prototype for other dysmotility treatment paradigms, and to yield insights for new technological interfaces between non-invasiveness and surgery.
Le texte complet de cet article est disponible en PDF.Abbreviations : ESP, ESPI, GES, PEG
Plan
| DISCLOSURE: T. Abell is an investigator, speaker, consultant, and licensor for Medtronic Inc. Certain aspects of this technology are covered in intellectual property filed by the University of Texas Arlington and the University of Mississippi. J. Chiao is a consultant for Alcon. J. Easter and T. McLawhorn are employees of Cook Medical. No other financial relationships relevant to this publication were disclosed. |
Vol 76 - N° 1
P. 179-184 - juillet 2012 Retour au numéro
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