Tissue factor–dependent thrombin generation across pregnancy - 26/07/12
Reprints: Kathleen E. Brummel-Ziedins, PhD, Department of Biochemistry, 208 S Park Dr., Room 235, University of Vermont, Colchester, VT 05446Résumé |
Objective |
Normal pregnancy results in a prothrombotic state. Studies that have investigated the capacity of pregnant women to generate thrombin are limited. Our aim was to evaluate thrombin generation longitudinally from the preconception period, through pregnancy, and after pregnancy.
Study Design |
We evaluated young, healthy nulligravid women (n = 20) at 4 time points and compared the data with 10 control women at 2 time points. Coagulation was initiated with tissue factor in contact pathway inhibited plasma, and thrombin generation was determined in the presence of a fluorogenic substrate.
Results |
The maximum level and rate of thrombin generation increased during pregnancy; the highest level and rate occurred in late pregnancy compared with prepregnancy (P < .001). Subsequently, thrombin generation decreased in the postpregnancy samples that included maximum level, rate, and area under the curve (P < .001).
Conclusion |
Our data provide evidence for an increase in tissue factor–dependent thrombin generation with pregnancy progression, followed by a return to prepregnancy thrombin levels.
Le texte complet de cet article est disponible en PDF.Key words : longitudinal study, pregnancy, thrombin generation
Plan
| Supported by internal University of Vermont Maternal-Fetal Medicine Fellowship funding (Dr McLean), National Institutes of Health grant numbers HL46703–Project 5 (Dr Brummel-Ziedins) and HL 71944 (Dr Bernstein). |
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| The authors report no conflict of interest. |
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| Cite this article as: McLean KC, Bernstein IM, Brummel-Ziedins KE. Tissue factor–dependent thrombin generation across pregnancy. Am J Obstet Gynecol 2012;207:135.e1-6. |
Vol 207 - N° 2
P. 135.e1-135.e6 - août 2012 Retour au numéro
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