Assessing Performance Trends in Laparoscopic Nephrectomy and Nephron-sparing Surgery for Localized Renal Tumors - 03/08/12

Doi : 10.1016/j.urology.2012.02.067

Marc C. Smaldone ^a, Alexander Kutikov ^a, Brian Egleston ^b, Jay Simhan ^a, Daniel J. Canter ^a, Ervin Teper ^a, Rosalia Viterbo ^a, David Y.T. Chen ^a, Richard E. Greenberg ^a, Robert G. Uzzo ^a,^⁎
^a Division of Urological Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA
^b Department of Biostatistics & Bioinformatics, Fox Chase Cancer Center, Philadelphia, PA

Reprint requests: Robert G. Uzzo, M.D., Department of Surgery, Division of Urologic Oncology, Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111

Résumé

Objective

To assess the impact of laparoscopy on usage of partial nephrectomy (PN) by comparing national usage trends in patients undergoing surgery for localized renal tumors.

Methods

Using linked Surveillance, Epidemiology, and End Results (SEER)–Medicare data, we retrospectively examined trends in procedure usage from 1995 to 2007 for patients undergoing surgery for localized (stage I/II) renal masses. Procedures were classified as open radical nephrectomy (ORN), laparoscopic radical nephrectomy (LRN), open partial nephrectomy (OPN), and laparoscopic partial nephrectomy (LPN). Patients were further stratified by tumor size (≤4 cm, >4– ≤7 cm, >7 cm). Data were primarily analyzed using logistic regressions.

Results

Patients (n = 11,689, mean age 74.4 ± 5.7 years, 56% male) with a mean tumor size of 4.7 ± 3.3 cm met the inclusion criteria. From 1995 to 2007, ORN rates decreased and for each year successive year patients were more likely to be treated with OPN (odds ratio [OR] 1.17, 95% confidence interval [CI] 1.14-1.19), LRN (OR 1.44, CI 1.41-1.47), and LPN (OR 1.75, CI 1.68-1.83). Although the increased usage of OPN (7.5% vs 13.6%, P < .001) and LPN (0% vs 14.2%, P < .001) reached statistical significance, this was offset by a marked increase in LRN over the same time period (3.0% vs 43.0%, P < .001).

Conclusion

Despite increasing emphasis on nephron preservation, PN usage rates remain low. Compared with a 40% increase in LRN, use of PN increased by only 20% from 1995 to 2007. As a result, 72% of identified Medicare beneficiaries with localized tumors were managed with radical nephrectomy (RN) in 2007. The trade-off of minimally invasive surgery for nephron preservation may have adverse long-term consequences.

Le texte complet de cet article est disponible en PDF.

Plan

Financial Disclosure: The authors declare that they have no relevant financial interests.

Funding Support: This publication was supported in part by grant number P30 CA006927 from the National Cancer Institute (to RGU). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. The authors were supported in part through the National Institutes of Health R03CA152388 (to BLE), and Department of Defense, physician Research Training Award (to AK).